Mutation detail:
| Mutation site | I38T |
| Virus | Influenzavirus A H1N1 |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | PA |
| Gene ID | 23308128 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | FJ966081.1 |
| Drug/antibody/vaccine | baloxavir resistant |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Polymerase PA |
| Uniprot protein ID | C3W5X6 |
| Protein length | 716 amino acids |
| Protein description | PA Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity. |
Literature information:
| Pubmed ID | 31419295 |
| Clinical information | No |
| Disease | - |
| Published year | 2020 |
| Journal | The Journal of Infectious Diseases |
| Title | Impact of the Baloxavir-Resistant Polymerase Acid I38T Substitution on the Fitness of Contemporary Influenza A(H1N1)pdm09 and A(H3N2) Strains |
| Author | Liva Checkmahomed,Zeineb M.hamdi,Julie Carbonneau,Marie-Christine Venable,Mariana Baz |
| Evidence | Impact of the I38T PA mutation in mice experimentally infected with A(H1N1)pdm09 viruses.A, Mean body weight loss standard deviation of mice infected with recombinant A(H1N1)pdm09 wild-type (WT) and mutant viruses. Groups of 6 mice were infected with 720 plaque-forming units of the recombinant A(H1N1)pdm09 and its I38T variant |