Mutation detail:
| Mutation site | K186R |
| Virus | Varicella-Zoster virus |
Mutation level  |
Amino acid level |
| Gene/protein/region type | ORF36 |
| Gene ID | 1487667 |
| Country | German |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | X04370.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Thymidine Kinase |
| Uniprot protein ID | P09250 |
| Protein length | 341 amino acids |
| Protein description | Thymidine kinase catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors. |
Literature information:
| Pubmed ID | 28886462 |
| Clinical information | No |
| Disease | - |
| Published year | 2017 |
| Journal | Journal of Clinical Virology |
| Title | Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades |
| Author | Anja Hoffmanna,Kristin Döringa,Natalja Tatjana Seegera,Martina Buhlera,Michael Schackea |
| Evidence | In the TK, four isolates (one: varicella, three: zoster) harbored the substitutions S51L, N119D, K186R, and V194A resulting in a mutagenesis rate of 2.4% and a rate of 0.024 substitutions per strain. |