Mutation detail:
| Mutation site | D645Y |
| Virus | Varicella-Zoster virus |
Mutation level  |
Amino acid level |
| Gene/protein/region type | ORF28 |
| Gene ID | 1487712 |
| Country | German |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | X04370.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | DNA polymerase catalytic subunit |
| Uniprot protein ID | Q4JQU7 |
| Protein length | 1194 amino acids |
| Protein description | DNA polymerase catalytic subunit is the replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication (By similarity). |
Literature information:
| Pubmed ID | 28886462 |
| Clinical information | No |
| Disease | - |
| Published year | 2017 |
| Journal | Journal of Clinical Virology |
| Title | Genetic polymorphism of thymidine kinase (TK) and DNA polymerase (pol) of clinical varicella-zoster virus (VZV) isolates collected over three decades |
| Author | Anja Hoffmanna,Kristin Döringa,Natalja Tatjana Seegera,Martina Buhlera,Michael Schackea |
| Evidence | In total, 0.23 substitutions of the DNA pol were found per strain. Out of the isolates with DNA pol substitutions, 16 (six: varicella, nine: zoster, one: diagnosis not known) exhibited one of the following 14 novel changes with hitherto unknown influence |