Mutation detail:
| Mutation site | D53G |
| Virus | SARS-CoV-2 |
Mutation level  |
Amino acid level |
| Gene/protein/region type | ORF6 |
| Gene ID | 43740572 |
| Country | USA |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_045512.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | ORF6 protein |
| Uniprot protein ID | P0DTC6 |
| Protein length | 61 amino acids |
| Protein description | ORF6 encodes a viral accessory protein. Based on its similarity to other coronavirus proteins, ORF6 protein is thought to play a role in viral pathogenesis.The functions of orf6 are as follows: 1) it binds the nsp8 in the replication\transcription complex which reflects its importance for the viral replication, 2) it increases the infection titer, 3) it contributes to the evasion of the virus to the host immune system through inhibition of the interferon induction and signaling pathway; it inhibits the Signal Transduction and Activator of Transcription (STAT 1), and 4) it participates in the formation of the DMV in the host cells which helps in protein trafficking to ensure the assembling of the virus. |
Literature information:
| Pubmed ID | 34147651 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | INFECTION GENETICS AND EVOLUTION |
| Title | Global variation in SARS-CoV-2 proteome and its implication in pre-lockdown emergence and dissemination of 5 dominant SARS-CoV-2 clades |
| Author | L Ponoop Prasad Patro, Chakkarai Sathyaseelan, Patil Pranita Uttamrao, Thenmalarchelvi Rathinavelan |
| Evidence | To track the emergence as well as the persistence of mutations during the early stage of the pandemic, a comparative analysis of SARS-CoV-2 whole proteome sequences has been performed by considering manually curated 31,389 whole genome sequences from 84 countries.Supplementary material 2 |