Mutation detail:
| Mutation site | E53D |
| Virus | Human respiratory syncytial virus |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | P |
| Gene ID | 1494471 |
| Country | USA |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | A |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | KF973319.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Phosphoprotein |
| Uniprot protein ID | P03421 |
| Protein length | 241 amino acids |
| Protein description | Phosphoprotein plays critical roles in regulating RNA replication and transcription through its interactions with multiple proteins. Tethers the RNA-directed RNA polymerase L to the nucleoprotein-RNA complex. Recruits the M2-1 protein, a processivity factor that is required for efficient transcription of viral RNA. Acts as a chaperone for neo-synthesized nucleoprotein by forming an N-P complex that preserves N in a monomeric and RNA-free state and prevents the association of nascent N with host cell RNAs . Recruits the host phosphatase PP1 to inclusion bodies to regulate viral transcription. Together with the nucleoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway |
Literature information:
| Pubmed ID | 24741088 |
| Clinical information | No |
| Disease | - |
| Published year | 2014 |
| Journal | Journal Of Virology |
| Title | Within-host whole-genome deep sequencing and diversity analysis of human respiratory syncytial virus infection reveals dynamics of genomic diversity in the absence and presence of immune pressure |
| Author | Yonatan H Grad, Ruchi Newman, Michael Zody, Xiao Yang, Ryan Murphy |
| Evidence | FIG 2 |