Mutation detail:
| Mutation site | D839E |
| Virus | SARS-CoV-2 |
Mutation level  |
Amino acid level |
| Gene/protein/region type | S |
| Gene ID | 43740568 |
| Country | Netherlands |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | 20B |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | MN908947 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Spike glycoprotein |
| Uniprot protein ID | P0DTC2 |
| Protein length | 1273 amino acids |
| Protein description | Spike protein is one of the structural proteins of SARS-CoV-2. The monomeric protein consists of one large ectodomain, a single-pass transmembrane anchor, and a short intracellular tail at C-terminus. It encompasses 22 glycosylation sites. S protein cleaves into two subunits namely S1 and S2 following receptor recognition. Receptor Binding Domain (RBD) in S1 subunit plays a major role in ACE2 receptor binding. |
Literature information:
| Pubmed ID | 33131453 |
| Clinical information | No |
| Disease | - |
| Published year | 2020 |
| Journal | Emerging Microbes & Infections |
| Title | Massive dissemination of a SARS-CoV-2 Spike Y839 variant in Portugal |
| Author | Vitor Borges,Joana Isidro,Helena Cortes-Martins,Silvia Duarte,Joao Paulo Gomes |
| Evidence | Table S2. List of SARS-CoV-2 Spike amino acid sequences with mutations in the 839 site available at GISAID, as of July 23rd, 2020. |