AVM v1, released 02-OCT-22

A manually curated database of aerosol-transmitted virus mutations, human diseases, and drugs

Mutation detail:


Mutation site E3Q
Virus SARS-CoV-2
Mutation level Amino acid level
Gene/protein/region type ORF7b
Gene ID
Country India
Mutation type nonsynonymous mutation
Genotype/subtype/clade -
Sample Human
Variants -
Viral reference sequence NC_045512.2
Drug/antibody/vaccine -
Transmissibility -
Transmission mechanism -
Pathogenicity -
Pathogenicity mechanism -
Immune escape mutation -
Immune escape mechanism -
RT-PCR primers probes -

Protein detail:


Protein name ORF7b
Uniprot protein ID -
Protein length 43 amino acids
Protein description ORF7b encodes a viral accessory protein. Based on its similarity to other coronavirus proteins, ORF7b protein is thought to localize to the Golgi compartment. The orf7b is a hydrophobic protein with a transmembrane domain N-terminal at the outside, and a cytoplasmic C-terminal. Similar to orf7a, orf7b is reported by the majority of the previous studies that it is not essential for virus replication.

Literature information:


Pubmed ID 33368386
Clinical information No
Disease -
Published year 2021
Journal JOURNAL OF MEDICAL VIROLOGY
Title Dynamic tracking of variant frequencies depicts the evolution of mutation sites amongst SARS-CoV-2 genomes from India
Author Shenu Hudson B,Vaishnavi Kolte,Azra Khan,Gaurav Sharma
Evidence The mutational probabilities of these 118 sites across all time points (month-wise) were visualized using a clustered heatmap where six clusters were obtained with 4, 3, 2, 5, 5, and 99 sites per cluster (Figure 1A,B and Table S2).