Mutation detail:
| Mutation site | E484Q |
| Virus | SARS-CoV-2 |
Mutation level  |
Amino acid level |
| Gene/protein/region type | S |
| Gene ID | 43740568 |
| Country | France |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | 20I |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC 045512.2 |
| Drug/antibody/vaccine | bamlanivimab resistant |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | Yes |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Spike glycoprotein |
| Uniprot protein ID | P0DTC2 |
| Protein length | 1273 amino acids |
| Protein description | Spike protein is one of the structural proteins of SARS-CoV-2. The monomeric protein consists of one large ectodomain, a single-pass transmembrane anchor, and a short intracellular tail at C-terminus. It encompasses 22 glycosylation sites. S protein cleaves into two subunits namely S1 and S2 following receptor recognition. Receptor Binding Domain (RBD) in S1 subunit plays a major role in ACE2 receptor binding. |
Literature information:
| Pubmed ID | 34352197 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | EMERGING INFECTIOUS DISEASES |
| Title | SARS-CoV-2 Variants in Immunocompromised Patient Given Antibody Monotherapy |
| Author | Aurelie Truffot, Julien Andreani, Marion Le Marechal, Alban Caporossi, Olivier Epaulard |
| Evidence | This analysis detected clade 20I/501Y.V1, Alpha variant (Pangolin: B.1.1.7), on day 3 in nasopharyngeal swab specimens. Three days later (day 6), a novel mutation (G23012C, S: E484Q) appeared in nasopharyngeal swab specimens at frequency of 82%, which rapidly reached >99% (S: E484Q) 10 days after mAb treatment (Table; Figure). Eleven days after the mAb infusion, we detected an additional nucleotide mutation A23040G (S: Q493R) in only a blood sample at a frequency of 64%. This rate reached 76% at day 17 without any detection in nasopharyngeal swab specimens. |