Mutation detail:
| Mutation site | 4402G>A |
| Virus | Varicella-Zoster virus |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | ORF5 |
| Gene ID | 1487673 |
| Country | Canada |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_001348.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Envelope Glycoprotein K |
| Uniprot protein ID | P09261 |
| Protein length | 340 amino acids |
| Protein description | Envelope Glycoprotein K that probably modulates membrane fusion events during secondary envelopment of cytoplasmic capsids that bud into specific trans-Golgi network (TGN)-derived membranes. Also plays a role, together with gB, in virus-induced cell-to-cell fusion (syncytia formation), which is extensive during VZV infection in cultured cells |
Literature information:
| Pubmed ID | 22837206 |
| Clinical information | No |
| Disease | - |
| Published year | 2012 |
| Journal | JOURNAL OF VIROLOGY |
| Title | The Attenuated Genotype of Varicella-Zoster Virus Includes an ORF0 Transitional Stop Codon Mutation |
| Author | Geoffrey A Peters,Shaun D Tyler,John E Carpenter,Wallen Jackson,Yasuko Mori |
| Evidence | Table1 |