AVM

Mutation site	2485G>A
Virus	Human respiratory syncytial virus
Mutation level	Nucleotide Level
Gene/protein/region type	P
Gene ID	1494471
Country	USA
Mutation type	-
Genotype/subtype/clade	A
Sample	Human
Variants	-
Viral reference sequence	KT992094.1
Drug/antibody/vaccine	-
Transmissibility	-
Transmission mechanism	-
Pathogenicity	-
Pathogenicity mechanism	-
Immune escape mutation	-
Immune escape mechanism	-
RT-PCR primers probes	-

Protein name	Phosphoprotein
Uniprot protein ID	P03421
Protein length	241 amino acids
Protein description	Phosphoprotein plays critical roles in regulating RNA replication and transcription through its interactions with multiple proteins. Tethers the RNA-directed RNA polymerase L to the nucleoprotein-RNA complex. Recruits the M2-1 protein, a processivity factor that is required for efficient transcription of viral RNA. Acts as a chaperone for neo-synthesized nucleoprotein by forming an N-P complex that preserves N in a monomeric and RNA-free state and prevents the association of nascent N with host cell RNAs . Recruits the host phosphatase PP1 to inclusion bodies to regulate viral transcription. Together with the nucleoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway

Pubmed ID	32006006
Clinical information	No
Disease	-
Published year	2020
Journal	The Journal of infectious diseases
Title	Live-Attenuated Respiratory Syncytial Virus Vaccine With M2-2 Deletion and With Small Hydrophobic Noncoding Region Is Highly Immunogenic in Children
Author	Elizabeth J McFarland,Ruth A Karron,Petronella Muresan,Coleen K Cunningham,Charlotte Perlowski
Evidence	A nucleotide dimorphism at nucleotide 2485 (about 20% of the virus population containing a G2485A mutation at this site), which would result in a 20% subpopulation with a D47N amino acid change in the P ORF;