Mutation detail:
| Mutation site | 65669C>T |
| Virus | Varicella-Zoster virus |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | ORF36 |
| Gene ID | 1487667 |
| Country | - |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | X04370.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Thymidine Kinase |
| Uniprot protein ID | P09250 |
| Protein length | 341 amino acids |
| Protein description | Thymidine kinase catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors. |
Literature information:
| Pubmed ID | 1848597 |
| Clinical information | No |
| Disease | - |
| Published year | 1991 |
| Journal | JOURNAL OF VIROLOGY |
| Title | Analysis of mutations in the thymidine kinase genes of drug-resistant varicella-zoster virus populations using the polymerase chain reaction |
| Author | S. F. Lacey, L2 T. Suzutani, ~ K. L. Powell, 2. D. J. M. Purifoy 2 and R. W. Honess I |
| Evidence | In addition, all 21 subclones of these strain YS-derived genes had a silent mutation ( T : A to C : G at position 64989) relative to the VZV strain Dumas D N A sequence (Davison & Scott, 1986) and the C : G to T : A change at position 65669 which results |