Mutation detail:
| Mutation site | T127I |
| Virus | MERS-CoV |
Mutation level  |
Amino acid level |
| Gene/protein/region type | M Protein |
| Gene ID | 14254600 |
| Country | Saudi Arabia |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | JX869059.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Membrane Protein |
| Uniprot protein ID | K9N7A1 |
| Protein length | 219 amino acids |
| Protein description | Membrane Protein is present in high amounts out of all proteins in coronaviruses. Its length spans to about 219 amino acids with a short length N terminal domain, attached to triple transmembrane domains that are further connected to a carboxyl-terminal domain and belong to the N-linked glycosylated proteins with a conserved domain of 12 amino acids. Out of the three TDM, the first one is capable enough to encourage self-association of M proteins, improved membrane affinity, and retention in Golgi. The membrane protein is a transmembrane glycoprotein, is the most abundant structural protein in the virus particle and has been suggested as an antiviral drug target. |
Literature information:
| Pubmed ID | 32654959 |
| Clinical information | Yes |
| Disease | - |
| Published year | 2020 |
| Journal | International Journal of Environmental Research and Public Health |
| Title | Evolving sequence mutations in the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) |
| Author | Mohammed Ali AlBalwi, Anis Khan, Mohammed AlDrees, Udayaraja Gk, Balavenkatesh Manie |
| Evidence | Table 2 |