AVM v1, released 02-OCT-22

A manually curated database of aerosol-transmitted virus mutations, human diseases, and drugs

Mutation detail:

Mutation site H42Y
Virus SARS-CoV-2
Mutation level Amino acid level
Gene/protein/region type ORF7b
Gene ID
Country England
Mutation type nonsynonymous mutation
Genotype/subtype/clade -
Sample Human
Variants -
Viral reference sequence NC_045512.2
Drug/antibody/vaccine -
Transmissibility -
Transmission mechanism -
Pathogenicity -
Pathogenicity mechanism -
Immune escape mutation -
Immune escape mechanism -
RT-PCR primers probes -

Protein detail:

Protein name ORF7b
Uniprot protein ID -
Protein length 43 amino acids
Protein description ORF7b encodes a viral accessory protein. Based on its similarity to other coronavirus proteins, ORF7b protein is thought to localize to the Golgi compartment. The orf7b is a hydrophobic protein with a transmembrane domain N-terminal at the outside, and a cytoplasmic C-terminal. Similar to orf7a, orf7b is reported by the majority of the previous studies that it is not essential for virus replication.

Literature information:

Pubmed ID 34147651
Clinical information No
Disease -
Published year 2021
Journal INFECTION GENETICS AND EVOLUTION
Title Global variation in SARS-CoV-2 proteome and its implication in pre-lockdown emergence and dissemination of 5 dominant SARS-CoV-2 clades
Author L Ponoop Prasad Patro, Chakkarai Sathyaseelan, Patil Pranita Uttamrao, Thenmalarchelvi Rathinavelan
Evidence To track the emergence as well as the persistence of mutations during the early stage of the pandemic, a comparative analysis of SARS-CoV-2 whole proteome sequences has been performed by considering manually curated 31,389 whole genome sequences from 84 countries.Supplementary material 2

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