Mutation detail:
| Mutation site | L283F |
| Virus | MERS-CoV |
Mutation level  |
Amino acid level |
| Gene/protein/region type | N Protein |
| Gene ID | 14254601 |
| Country | Saudi Arabia |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | JX869059.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Nucleocapsid Protein |
| Uniprot protein ID | K9N4V7 |
| Protein length | 413 amino acids |
| Protein description | The Nucleocapsid Phosphoprotein has a modular organization which can be divided into intrinsically disordered regions (IDRs) and conserved structural regions according to the sequence characteristics. The IDRs include three modules: N-arm, central Ser/Arg-rich flexible linker region (LKR), and C-tail, while the conserved structural regions including two modules: N-terminal domain (NTD) and C-terminal domain (CTD). In the primary structure, NTD and CTD are connected by LKR and are usually flanked by N-arm and C-tail. The nucleocapsid phosphoprotein is a structural protein that binds to, protects the viral RNA genome and is involved in packaging the RNA into virus particles. The N protein has been suggested as an antiviral drug target. |
Literature information:
| Pubmed ID | 32654959 |
| Clinical information | Yes |
| Disease | - |
| Published year | 2020 |
| Journal | International Journal of Environmental Research and Public Health |
| Title | Evolving sequence mutations in the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) |
| Author | Mohammed Ali AlBalwi, Anis Khan, Mohammed AlDrees, Udayaraja Gk, Balavenkatesh Manie |
| Evidence | Table 2 |