Mutation detail:
| Mutation site | L244del/H245del/R246del/S247del |
| Virus | SARS-CoV-2 |
Mutation level  |
Amino acid level |
| Gene/protein/region type | S |
| Gene ID | 43740568 |
| Country | Germany |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_045512.2 |
| Drug/antibody/vaccine | lvermectin resistant |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | Yes |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Spike glycoprotein |
| Uniprot protein ID | P0DTC2 |
| Protein length | 1273 amino acids |
| Protein description | Spike protein is one of the structural proteins of SARS-CoV-2. The monomeric protein consists of one large ectodomain, a single-pass transmembrane anchor, and a short intracellular tail at C-terminus. It encompasses 22 glycosylation sites. S protein cleaves into two subunits namely S1 and S2 following receptor recognition. Receptor Binding Domain (RBD) in S1 subunit plays a major role in ACE2 receptor binding. |
Literature information:
| Pubmed ID | 34737266 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | Nature Communications |
| Title | Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants |
| Author | Sebastian Weigang, Jonas Fuchs, Gert Zimmer, Daniel Schnepf, Lisa Kern |
| Evidence | Analysis of the viral RNA that had been extracted from the patient samples revealed several nucleotide substitutions in ORF1ab, the spike gene, ORF3a, M, and N genes in comparison to the Wuhan-Hu-1 reference genome (Fig. 2c). The continuous presence of nine common mutations in all sequences argues against possible reinfection but is compatible with viral persistence. Within the first two weeks, no changes in the viral genome were observed, while from day 42 onward acquisition of several mutations occurred. Apart from low-frequency mutations, some mutations accumulated over time are indicative for the selection of distinct variants. |