Mutation detail:
| Mutation site | 25286T>A |
| Virus | SARS-CoV |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | ORF3a |
| Gene ID | 1489669 |
| Country | China |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | AY390556.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | ORF3a Protein |
| Uniprot protein ID | P59632 |
| Protein length | 274 amino acids |
| Protein description | The accessory protein orf3a of SARS-CoV is located between the spike and the E protein genes. The N-terminus of the protein is found at the extracellular side, while the C-terminus is located on the intracellular side. Also, it contains a cysteine-rich domain. The N-terminal domain of the orf3a protein contains three transmembrane domains. The orf3a plays a role in the viral envelope assembly, host cell binding and infusion since it interacts with the structural proteins (M, S, and E) and the accessory protein (7a) of SARS-CoV. |
Literature information:
| Pubmed ID | 14752165 |
| Clinical information | No |
| Disease | - |
| Published year | 2004 |
| Journal | Science |
| Title | Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China |
| Author | Chinese SARS Molecular Epidemiology Consortium |
| Evidence | Table s2 |