Mutation detail:
| Mutation site | P188L |
| Virus | Varicella-Zoster virus |
Mutation level  |
Amino acid level |
| Gene/protein/region type | ORF35 |
| Gene ID | 1487688 |
| Country | Canada |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_001348.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Nuclear Protein UL24 |
| Uniprot protein ID | Q4JQU0 |
| Protein length | 258 amino acids |
| Protein description | ORF35 is located in the UL region of the genome and is predicted to encode a protein of about 258 amino acids. It may participate in nuclear egress of viral particles. Plays a role in the dispersal of several host nucleolar proteins including NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively impact on nuclear egress, UL24 supposedly acts on this process through its effect on host nucleoli (By similarity). |
Literature information:
| Pubmed ID | 22837206 |
| Clinical information | No |
| Disease | - |
| Published year | 2012 |
| Journal | JOURNAL OF VIROLOGY |
| Title | The Attenuated Genotype of Varicella-Zoster Virus Includes an ORF0 Transitional Stop Codon Mutation |
| Author | Geoffrey A Peters,Shaun D Tyler,John E Carpenter,Wallen Jackson,Yasuko Mori |
| Evidence | Table1 |