Mutation detail:
| Mutation site | L9P |
| Virus | SARS-CoV-2 |
Mutation level  |
Amino acid level |
| Gene/protein/region type | ORF7a |
| Gene ID | 43740573 |
| Country | Brazil |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_045512.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | ORF7a protein |
| Uniprot protein ID | P0DTC7 |
| Protein length | 121 amino acids |
| Protein description | The orf 7a of SARS-CoV-2 is a transmembrane protein with four regions from the N-terminal: 1) the first 15 amino acids form a signal peptide which is hydrolyzed by the infected host cells; 2) the amino acids from 16 to 96 constitute the intracellular domain; 3) the 97- 117 amino acids are hydrophobic amino acids constituting a transmembrane domain; and 4) the last five amino acids constitute the C- terminal of the orf7a. The orf7a interacts with the S, M, E, and the orf3a proteins, which suggest a role of the protein in the assembling of the virus and in the binding and invasion of the virus to the host cells. |
Literature information:
| Pubmed ID | 34099808 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | Scientific Reports |
| Title | SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions |
| Author | Luis Fernando Saraiva Macedo Timmers,Julia Vasconcellos Peixoto,Rodrigo Gay Ducati,Jose Fernando Ruggiero Bachega,Leandro de Mattos Pereira |
| Evidence | We combined genomic and structural analysis to evaluate genomes isolated from different regions of Brazil and show that the most prevalent mutations were located in the S, N, ORF3a and ORF6 genes, which are involved in different stages of viral life cycle and its interaction with the host cells.(Supplementary Information) |