Mutation detail:
| Mutation site | M1229I |
| Virus | SARS-CoV-2 |
Mutation level  |
Amino acid level |
| Gene/protein/region type | S |
| Gene ID | 43740568 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | MN908947.3 |
| Drug/antibody/vaccine | - |
| Transmissibility |
hinder |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Spike glycoprotein |
| Uniprot protein ID | P0DTC2 |
| Protein length | 1273 amino acids |
| Protein description | Spike protein is one of the structural proteins of SARS-CoV-2. The monomeric protein consists of one large ectodomain, a single-pass transmembrane anchor, and a short intracellular tail at C-terminus. It encompasses 22 glycosylation sites. S protein cleaves into two subunits namely S1 and S2 following receptor recognition. Receptor Binding Domain (RBD) in S1 subunit plays a major role in ACE2 receptor binding. |
Literature information:
| Pubmed ID | 34645933 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | Communications Biology |
| Title | Ten emerging SARS-CoV-2 spike variants exhibit variable infectivity, animal tropism, and antibody neutralization |
| Author | Li Zhang, Zhimin Cui, Qianqian Li, Bo Wang, Yuanling Yu |
| Evidence | The single mutations M1229I may be the key mutation that caused the decreased infectivity of B.1.1.298 (Supplementary Fig. 1), while the expression level of B.1.1.298 spike protein was significantly decreased compared to D614G mutation, which may be responsible for the observed reduced infection (Supplementary Fig. 2). |