AVM

Protein name	Hemagglutinin
Uniprot protein ID	C3W627
Protein length	566 amino acids
Protein description	The HA protein is translated as an uncleaved HA0 precursor protein, folded as a trimer, and glycosylated and acylated. The HA protein binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Pubmed ID	21288815
Clinical information	No
Disease	-
Published year	2011
Journal	The Journal of Infectious Diseases
Title	Deep Sequencing Reveals Mixed Infection with 2009 Pandemic Influenza A (H1N1) Virus Strains and the Emergence of Oseltamivir Resistance
Author	Elodie Ghedin,Jennifer Laplante,Jay DePasse,David E. Wentworth,Roberto P. Santos
Evidence	Sanger consensus sequence assemblies of both samples also revealed a unique set of residues, compared with the pandemic H1N1/2009 virus strains available in public databases: specifically, a D199N mutation in the NA, a N55D mutation in the HA, and a R626K mutation in the polymerase.