Mutation detail:
| Mutation site | 26203C>T |
| Virus | SARS-CoV |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | E Protein |
| Gene ID | 1489671 |
| Country | China |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | AY390556.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Small Envelope Protein |
| Uniprot protein ID | P59637 |
| Protein length | 76 amino acids |
| Protein description | The E protein of SARS coronavirus contains three domains, N- terminal domain, transmmebrane domain, and C-terminal domain. The C- terminal localizes in the Endoplasmic Reticulum and Golgi complex to participate in the assembling and budding of the virions inside the host cells. The functions of the E protein include the assembly of the virion envelope; suppression of the host cells stress responses which is important for the downregulation of immune response and promotion of pathogenesis. |
Literature information:
| Pubmed ID | 14752165 |
| Clinical information | No |
| Disease | - |
| Published year | 2004 |
| Journal | Science |
| Title | Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China |
| Author | Chinese SARS Molecular Epidemiology Consortium |
| Evidence | Table s2 |