AVM

Protein name	Hemagglutinin
Uniprot protein ID	C3W627
Protein length	566 amino acids
Protein description	The HA protein is translated as an uncleaved HA0 precursor protein, folded as a trimer, and glycosylated and acylated. The HA protein binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Pubmed ID	21364825
Clinical information	No
Disease	-
Published year	2010
Journal	Bioinformation
Title	Identification of sequence mutations affecting hemagglutinin specificity to sialic acid receptor in influenza A virus subtypes
Author	Usman Sumo Friend Tambunan,Ramdhan
Evidence	These mutation patterns identified include 1) mutations in positions 190 and 225 to aspartic acid (E190D in A/Brevig Mission/1/18(H1N1), A/New York/1/18(H1N1) and A/South Carolina/1/1918(H1N1) and G225D on A/South Carolina/1/1918(H1N1), A/South Carolina/1/1918(H1N1), and A/Puerto Rico/8/34(H1N1)) and 2) mutations in position 226 and 228 to leucine and serine (Q226L and G228S in A/Guiyang/1/1957(H2N2), A/Kayano/57(H2N2), A/Aichi/2/1968(H3N2) and A/Hong Kong/1/1968(H3N2), A/Memphis/1/68(H3N2)).