Mutation detail:
| Mutation site | P132A |
| Virus | SARS-CoV-2 |
Mutation level  |
Amino acid level |
| Gene/protein/region type | M |
| Gene ID | 43740571 |
| Country | Brazil |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_045512.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Membrane Glycoprotein |
| Uniprot protein ID | P0DTC5 |
| Protein length | 222 amino acids |
| Protein description | The membrane protein is present in high amounts out of all proteins in coronaviruses . Its length spans to about 220-260 amino acids with a short length N terminal domain, attached to triple transmembrane domains that are further connected to a carboxyl-terminal domain and belong to the N-linked glycosylated proteins with a conserved domain of 12 amino acids. Out of the three TDM, the first one is capable enough to encourage self-association of M proteins, improved membrane affinity, and retention in Golgi. The membrane protein is a transmembrane glycoprotein, is the most abundant structural protein in the virus particle and has been suggested as an antiviral drug target. |
Literature information:
| Pubmed ID | 34099808 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | Scientific Reports |
| Title | SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions |
| Author | Luis Fernando Saraiva Macedo Timmers,Julia Vasconcellos Peixoto,Rodrigo Gay Ducati,Jose Fernando Ruggiero Bachega,Leandro de Mattos Pereira |
| Evidence | We combined genomic and structural analysis to evaluate genomes isolated from different regions of Brazil and show that the most prevalent mutations were located in the S, N, ORF3a and ORF6 genes, which are involved in different stages of viral life cycle and its interaction with the host cells.(Supplementary Information) |