Mutation detail:
| Mutation site | L249P |
| Virus | Measles virus |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | H |
| Gene ID | 1489801 |
| Country | Spanish |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | D4 |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | U03669.1 |
| Drug/antibody/vaccine | MAb-BH129 resisitant, MAb-BH047 resisitant, MAb-BH059 resisitant |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | Yes |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Hemagglutinin Protein |
| Uniprot protein ID | P08362 |
| Protein length | 617 amino acids |
| Protein description | Hemagglutinin Protein attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis. |
Literature information:
| Pubmed ID | 28356529 |
| Clinical information | No |
| Disease | - |
| Published year | 2017 |
| Journal | Journal of Virology |
| Title | Antigenic Drift Defines a New D4 Subgenotype of Measles Virus |
| Author | Miguel Angel Munoz-Alia,Claude P Muller,Stephen J Russell |
| Evidence | Overall, these results show that an L249P substitution, but not S247P, impairs the binding of neutralizing antibodies that recognize the NE antigenic site, thereby allowing virus neutralization escape. |