Mutation detail:
| Mutation site | Q677H |
| Virus | SARS-CoV-2 |
Mutation level  |
Amino acid level |
| Gene/protein/region type | S |
| Gene ID | 43740568 |
| Country | USA |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | MN988713.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Spike glycoprotein |
| Uniprot protein ID | P0DTC2 |
| Protein length | 1273 amino acids |
| Protein description | Spike protein is one of the structural proteins of SARS-CoV-2. The monomeric protein consists of one large ectodomain, a single-pass transmembrane anchor, and a short intracellular tail at C-terminus. It encompasses 22 glycosylation sites. S protein cleaves into two subunits namely S1 and S2 following receptor recognition. Receptor Binding Domain (RBD) in S1 subunit plays a major role in ACE2 receptor binding. |
Literature information:
| Pubmed ID | 33090493 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | JOURNAL OF MEDICAL VIROLOGY |
| Title | Mutations in membrane-fusion subunit of spike glycoprotein play crucial role in the recent outbreak of COVID-19 |
| Author | Soumita Podder,Avishek Ghosh,Tapash Ghosh |
| Evidence | Multiple alignments of Spike protein sequences from 526 different isolates with one of the similar isolates have revealed a total of 31 Single Amino Acid Polymorphisms (SAPs) but none of them has occurred in the predicted IDR (671-708) which indicates the region is conserved among all of them (Figure 2A). |