Mutation detail:
| Mutation site | 5827C>A |
| Virus | Varicella-Zoster virus |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | ORF6 |
| Gene ID | 1487676 |
| Country | Canada |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_001348.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Helicase-Primase Primase Subunit |
| Uniprot protein ID | Q4JQW9 |
| Protein length | 1083 amino acids |
| Protein description | The helicase-primase complex unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase initiates primer synthesis and thereby produces large amount of short RNA primers on the lagging strand that the polymerase elongates using dNTPs. |
Literature information:
| Pubmed ID | 22837206 |
| Clinical information | No |
| Disease | - |
| Published year | 2012 |
| Journal | JOURNAL OF VIROLOGY |
| Title | The Attenuated Genotype of Varicella-Zoster Virus Includes an ORF0 Transitional Stop Codon Mutation |
| Author | Geoffrey A Peters,Shaun D Tyler,John E Carpenter,Wallen Jackson,Yasuko Mori |
| Evidence | Table1 |