Mutation detail:
| Mutation site | 27535T>G |
| Virus | SARS-CoV |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | ORF7a |
| Gene ID | 1489674 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | AY278741.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | ORF7a protein |
| Uniprot protein ID | P59635 |
| Protein length | 122 amino acids |
| Protein description | The orf7a of SARS-CoV is a transmembrane protein with four regions from the N-terminal: 1) the first 15 amino acids form a signal peptide which is hydrolyzed by the infected host cells; 2) the amino acids from 16 to 96 constitute the intracellular domain; 3) the 97- 117 amino acids are hydrophobic amino acids constituting a transmembrane domain; and 4) the last five amino acids constitute theC- terminal of the orf7a. The orf7a interacts with the S, M, E, and the orf3aproteins, which suggest a role of the protein in theassembling of the virus and in the binding and invasion of the virus to the host cells. Manystudies have proved that orf7a has no role in the replication of the virus. |
Literature information:
| Pubmed ID | 15347429 |
| Clinical information | No |
| Disease | - |
| Published year | 2004 |
| Journal | BMC INFECTIOUS DISEASES |
| Title | Mutational dynamics of the SARS coronavirus in cell culture and human populations isolated in 2003 |
| Author | Vinsensius B Vega, Yijun Ruan, Jianjun Liu, Wah Heng Lee, Chia Lin Wei |
| Evidence | Table S3 |