Mutation detail:
| Mutation site | 27749G>A |
| Virus | SARS-CoV |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | N Protein |
| Gene ID | 1489678 |
| Country | China |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_004718.3 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Nucleocapsid Protein |
| Uniprot protein ID | P59595 |
| Protein length | 422 amino acids |
| Protein description | The N- protein is an RNA-binding protein with many functions. Structurally, the N protein has three domains, N- terminal domain that binds the RNA, C- terminal domain responsible for dimerization, and a disordered central region rich in serine and arginine (SR).The functions of N protein include the formation of the helical viral RNA with its nucleoproteins, regulation of the viral replication and transcription, and modulation of the host cells metabolism to facilitate the replication, transport, release of the virus, and to help the virus escape the immune system of the host organism. |
Literature information:
| Pubmed ID | 16229772 |
| Clinical information | No |
| Disease | - |
| Published year | 2005 |
| Journal | Emerging Infectious Diseases |
| Title | Molecular epidemiology of SARS-associated coronavirus, Beijing |
| Author | Wei Liu, Fang Tang, Arnaud Fontanet, Lin Zhan, Tian-Bao Wang |
| Evidence | Table3 |