Mutation detail:
| Mutation site | R115H |
| Virus | SARS-CoV-2 |
Mutation level  |
Amino acid level |
| Gene/protein/region type | ORF8 |
| Gene ID | 43740577 |
| Country | Brazil |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_045512.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | ORF8 protein |
| Uniprot protein ID | P0DTC8 |
| Protein length | 121 amino acids |
| Protein description | The SARS-CoV-2 ORF8 gene spans 366 nucleotides (nt), is located between position 27,894 and 28,259 of the virus genome, following the ORF7b and preceding the N genes, respectively. The ORF8 gene is part of a hypervariable genomic region of - 430 bp in length that has been recognized as a recombination hotspot, also highly susceptible to deletions and nt substitutions. ORF8 protein comprehends an N-terminal signal peptide for transmembrane (TM) import and secretion, an internal -sandwich core and a C-terminal TM region followed by a stretch of basic residues. |
Literature information:
| Pubmed ID | 34099808 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | Scientific Reports |
| Title | SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions |
| Author | Luis Fernando Saraiva Macedo Timmers,Julia Vasconcellos Peixoto,Rodrigo Gay Ducati,Jose Fernando Ruggiero Bachega,Leandro de Mattos Pereira |
| Evidence | We combined genomic and structural analysis to evaluate genomes isolated from different regions of Brazil and show that the most prevalent mutations were located in the S, N, ORF3a and ORF6 genes, which are involved in different stages of viral life cycle and its interaction with the host cells.(Supplementary Information) |