Mutation detail:
| Mutation site | S13I/W152C |
| Virus | SARS-CoV-2 |
Mutation level  |
Amino acid level |
| Gene/protein/region type | S |
| Gene ID | 43740568 |
| Country | USA |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | NC_045512.2 |
| Drug/antibody/vaccine | mAb_4A8-resisitant,mAb_S2L26-resisitant,mAb_S2L50-resisitant,mAb_S2M28-resisitant,mAb_S2X28-resisitant,mAb_S2X303-resisitant,mAb_S2X158-resisitant,mAb_S2X107-resisitant,mAb_S2X333-resisitant,mAb_S2X124-resisitant |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | Yes |
| Immune escape mechanism | The S13I and W152C mutations resulted in total loss of neutralization for 10 of 10 NTD-specific mAbs because the NTD antigenic supersite was remodeled by a shift of the signal peptide cleavage site and the formation of a new disulfide bond, as revealed by |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Spike glycoprotein |
| Uniprot protein ID | P0DTC2 |
| Protein length | 1273 amino acids |
| Protein description | Spike protein is one of the structural proteins of SARS-CoV-2. The monomeric protein consists of one large ectodomain, a single-pass transmembrane anchor, and a short intracellular tail at C-terminus. It encompasses 22 glycosylation sites. S protein cleaves into two subunits namely S1 and S2 following receptor recognition. Receptor Binding Domain (RBD) in S1 subunit plays a major role in ACE2 receptor binding. |
Literature information:
| Pubmed ID | 34210893 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | Science |
| Title | SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern |
| Author | Matthew McCallum, Jessica Bassi, Anna De Marco, Alex Chen, Alexandra C Walls |
| Evidence | The two lineages B.1.427 and B.1.429 (belonging to clade 20C according to Nextstrain designation) share the same S mutations (S13I in the signal peptide, W152C in the NTD, and L452R in the RBD) but harbor different mutations in other SARS-CoV-2 genes |