Mutation detail:
| Mutation site | S253P |
| Virus | SARS-CoV-2 |
Mutation level  |
Amino acid level |
| Gene/protein/region type | ORF3a |
| Gene ID | 43740569 |
| Country | Brazil |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | 20J |
| Sample |
Human |
| Variants | Gamma |
| Viral reference sequence | NC_045512.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | ORF3a protein |
| Uniprot protein ID | P0DTC3 |
| Protein length | 275 amino acids |
| Protein description | ORF3a is a non-structural protein of SARS-CoV-2 localized at the surface. It is the largest accessory factor that contains 275 amino acids, and shows broad functions, such as enhancing viral entry within the host, regulating the pro-inflammatory cytokine and chemokine production, participating in ion channel formation as well as modulating release of virus from the host cell. |
Literature information:
| Pubmed ID | 34493762 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | Scientific Reports |
| Title | Dynamics of SARS-CoV-2 mutations reveals regional-specificity and similar trends of N501 and high-frequency mutation N501Y in different levels of control measures |
| Author | Santiago Justo Arevalo,Daniela Zapata Sifuentes,Cesar J Huallpa,Gianfranco Landa Bianchi, Adriana Castillo Chavez |
| Evidence | We identified 115 mutations with NRFp>0.03 (Fig. S1); this means that those mutations are estimated to be present in more than 3% of the COVID-19 cases globally. Considering that the sum of the reported cases from the 714 country-month combinations analyzed was 120,008,410 cases, an NRFp of more than 0.03 means that those mutations were present in more than 3,600,252 global COVID-19 cases. |