Mutation detail:
| Mutation site | I270A |
| Virus | Human respiratory syncytial virus |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | N |
| Gene ID | 1494470 |
| Country | Japan |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | A |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | AY911262.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Nucleoprotein |
| Uniprot protein ID | P03418 |
| Protein length | 391 amino acids |
| Protein description | Nucleoprotein Encapsidates the viral RNA genome by forming a left-handed helical nucleocapsid that protects the RNA from nucleases. RNA replication depends on the availability of soluble nucleoprotein. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. Together with the phosphoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway. May also act as a modulator of the innate immune response by sequestration of host IFIH1/MDA5 and MAVS into IBs. |
Literature information:
| Pubmed ID | 30626736 |
| Clinical information | No |
| Disease | - |
| Published year | 2019 |
| Journal | Journal of biological chemistry |
| Title | Biochemical characterization of the respiratory syncytial virus N0-P complex in solution |
| Author | Camille Esneau,Bertrand Raynal,Pierre Roblin,Sebastien Brule,Charles-Adrien Richard |
| Evidence | Among the 18 N variants tested, only 8 (V224A, M248A, L258A, V262A, V285A, G296A, I270A, and Y353A) were co-purified with GST-PCT with similar amounts compared with WT N. |