Mutation detail:
| Mutation site | S813I |
| Virus | SARS-CoV-2 |
Mutation level  |
Amino acid level |
| Gene/protein/region type | S |
| Gene ID | 43740568 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_045512.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Spike glycoprotein |
| Uniprot protein ID | P0DTC2 |
| Protein length | 1273 amino acids |
| Protein description | Spike protein is one of the structural proteins of SARS-CoV-2. The monomeric protein consists of one large ectodomain, a single-pass transmembrane anchor, and a short intracellular tail at C-terminus. It encompasses 22 glycosylation sites. S protein cleaves into two subunits namely S1 and S2 following receptor recognition. Receptor Binding Domain (RBD) in S1 subunit plays a major role in ACE2 receptor binding. |
Literature information:
| Pubmed ID | 33253058 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY |
| Title | A Gapless, Unambiguous RNA Metagenome-Assembled Genome Sequence of a Unique SARS-CoV-2 Variant Encoding Spike S813I and ORF1a A859V Substitutions |
| Author | May S Soliman, May AbdelFattah, Soad M N Aman, Lamyaa M Ibrahim, Ramy K Aziz |
| Evidence | Other than this unique variation, the spike protein in the CU_S3 genome carries three other variations from the reference Wuhan isolate, the most popular of which is the D614G variation that is becoming prevalent worldwide (88% frequency), and two more substitutions at positions 12 and 677 of the spike protein (S12F and Q677H, Fig. 1B, C) with frequencies of -0.11% and -0.19%, respectively. Another rather rare variation is an A-to-V substitution in residue 859 of ORF1a (amino acid 41 in NSP3), the one that encodes the replicase, and that has been seen in only 45/157,853 (-0.03%) global isolates (http://cov-glue.cvr.gla.ac.uk/#/project/replacement/NSP3:A:41:V), including one from Malaysia and one from Italy (Figs. 1D and 2A), and only one from Africa/Egypt (isolate CUNCI-HGC4I031). |