Mutation detail:
| Mutation site | T120I |
| Virus | SARS-CoV-2 |
Mutation level  |
Amino acid level |
| Gene/protein/region type | ORF7a |
| Gene ID | 43740573 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | Delta |
| Viral reference sequence | NC_045512.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | ORF7a protein |
| Uniprot protein ID | P0DTC7 |
| Protein length | 121 amino acids |
| Protein description | The orf 7a of SARS-CoV-2 is a transmembrane protein with four regions from the N-terminal: 1) the first 15 amino acids form a signal peptide which is hydrolyzed by the infected host cells; 2) the amino acids from 16 to 96 constitute the intracellular domain; 3) the 97- 117 amino acids are hydrophobic amino acids constituting a transmembrane domain; and 4) the last five amino acids constitute the C- terminal of the orf7a. The orf7a interacts with the S, M, E, and the orf3a proteins, which suggest a role of the protein in the assembling of the virus and in the binding and invasion of the virus to the host cells. |
Literature information:
| Pubmed ID | 34399188 |
| Clinical information | No |
| Disease | - |
| Published year | 2021 |
| Journal | JOURNAL OF AUTOIMMUNITY |
| Title | Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 viruses |
| Author | Saathvik R Kannan, Austin N Spratt, Alisha R Cohen, S Hasan Naqvi, Hitendra S Chand |
| Evidence | The Delta Plus variant had a significant number of high-prevalence mutations (-20 %) than in the Delta variant. Signature mutations in Spike (G142D, A222V, and T95I) existed at a more significant percentage in the Delta Plus variant than the Delta variant. Three mutations in Spike (K417N, V70F, and W258L) were exclusively present in the Delta Plus variant. A new mutation was identified in ORF1a (A1146T), which was only present in the Delta Plus variant with ~58 % prevalence. Furthermore, five key mutations (T95I, A222V, G142D, R158G, and K417N) were significantly more prevalent in the Delta Plus than in the Delta variant. |