Mutation detail:
| Mutation site | F129A |
| Virus | Varicella-Zoster virus |
Mutation level  |
Amino acid level |
| Gene/protein/region type | ORF44 |
| Gene ID | 1487718 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | AB097933.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Tegument Protein UL16 |
| Uniprot protein ID | P09293 |
| Protein length | 363 amino acids |
| Protein description | Tegument Protein UL16 plays a critical role in cytoplasmic virus egress. Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm by directly interacting with the capsid. Upon virion binding to target cell, a signaling cascade is triggered to disrupt the interaction with the capsid, thereby preparing capsid uncoating |
Literature information:
| Pubmed ID | 24155375 |
| Clinical information | No |
| Disease | - |
| Published year | 2014 |
| Journal | JOURNAL OF VIROLOGY |
| Title | Varicella-Zoster Virus ORF49 Functions in the Efficient Production of Progeny Virus through Its Interaction with Essential Tegument Protein ORF44 |
| Author | Tomohiko Sadaoka,Satoshi Serada,Junko Kato,Mayuko Hayashi,Yasuyuki Gomi |
| Evidence | Alanine substitutions in each domain rendered the ORF44F129A mutation lethal for VZV, similar to deletion of the entire ORF44. |