AVM

Protein name	Hemagglutinin
Uniprot protein ID	C3W627
Protein length	566 amino acids
Protein description	The HA protein is translated as an uncleaved HA0 precursor protein, folded as a trimer, and glycosylated and acylated. The HA protein binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Pubmed ID	21617302
Clinical information	No
Disease	-
Published year	2011
Journal	Japanese Journal of Infectious Diseases
Title	Genetic Analysis and Phylogenetic Characterization of Pandemic (H1N1) 2009 influenza viruses that found in Nagasaki, Japan
Author	Hiroaki Kawano,Takahiro Haruyama,Yuji Hayashi,Yoshinori Sinoda,Megumi Sonoda
Evidence	Amino acid alignment of the HA of Nagasaki isolates against global isolates was performed, and the results are summarized in Table 2.Among the Nagasaki isolates,A/Nagasaki/HA-58/2009 having an H275Y mutation in the neuraminidase gene, which confers resistance to oseltamivir, was isolated.