AVM

Protein name	Hemagglutinin
Uniprot protein ID	C3W627
Protein length	566 amino acids
Protein description	The HA protein is translated as an uncleaved HA0 precursor protein, folded as a trimer, and glycosylated and acylated. The HA protein binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Pubmed ID	16343533
Clinical information	No
Disease	-
Published year	2006
Journal	Journal of molecular biology
Title	Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities
Author	James Stevens,Ola Blixt,Laurel Glaser,Jeffery K Taubenberger,Peter Palese
Evidence	Remarkably,the only difference in 1918 H1 New York HA (A/NewYork/1918; 18NY) froman avian HA consensus RBSis a single Glu190Asp mutation (H3 numbering)(Table 1). South Carolina HA (A/South Carolina/1918; 18SC) has an additional Gly225Asp substitution.