Mutation detail:
| Mutation site | 24646T>C |
| Virus | Varicella-Zoster virus |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | ORF17 |
| Gene ID | 1487714 |
| Country | - |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | NC_001348.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Tegument Host Shutoff Protein |
| Uniprot protein ID | P09275 |
| Protein length | 455 amino acids |
| Protein description | VZV open reading frame 17 (ORF17) encodes a homolog of the HSV virion host shutoff protein.It has four domains that are highly conserved. Minor structural protein that acts as an endoribonuclease during lytic infection. Degrades host mRNAs in the cytoplasm by cutting them at preferred sites, including some in regions of translation initiation (By similarity). |
Literature information:
| Pubmed ID | 29242077 |
| Clinical information | No |
| Disease | - |
| Published year | 2017 |
| Journal | Virus Passaged in Cell Culture |
| Title | Vaccine-Type Mutations Identified in Varicella Zoster Virus Passaged in Cell Culture |
| Author | Seok Cheon Kim1 , Youn Hee Won1 , Ji Seon Park1 , Jeong Seon Jeon1 , Jin Hyun Ahn |
| Evidence | Table3 |