Mutation detail:
| Mutation site | 25903C>T |
| Virus | MERS-CoV |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | ORF4a |
| Gene ID | 14254596 |
| Country | Korea |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | NC_019843.3 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | ORF4a protein |
| Uniprot protein ID | K9N4V0 |
| Protein length | 109 amino acids |
| Protein description | ORF4a protein is one of the non-structural protein of MERS-CoV. ORF4a protein plays a role in the inhibition of host innate response. Suppresses host PACT-induced activation of DDX58 and MDA5 and thereby circumvents the production of type I inteferons. Prevents also the activation of host NF-kappaB. |
Literature information:
| Pubmed ID | 27900364 |
| Clinical information | Yes |
| Disease | - |
| Published year | 2016 |
| Journal | Cold Spring Harbor Molecular Case Studies |
| Title | Analysis of intrapatient heterogeneity uncovers the microevolution of Middle East respiratory syndrome coronavirus |
| Author | Donghyun Park,Hee Jae Huh,Yeon Jeong Kim,Dae-Soon Son,Hyo-Jeong Jeon |
| Evidence | Table 2 |