AVM

Protein name	Hemagglutinin
Uniprot protein ID	C3W627
Protein length	566 amino acids
Protein description	The HA protein is translated as an uncleaved HA0 precursor protein, folded as a trimer, and glycosylated and acylated. The HA protein binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Pubmed ID	21784793
Clinical information	No
Disease	-
Published year	2011
Journal	Bioinformatics
Title	Structural analysis of the hot spots in the binding between H1N1 HA and the 2D1 antibody: do mutations of H1N1 from 1918 to 2009 affect much on this binding?
Author	Qian Liu,Steven C H Hoi,Chinh T T Su,Zhenhua Li,Chee-Keong Kwoh
Evidence	Using the Z-score method, three of the six mutations-T133N, S159N and N171D-are predicted as non-hot spot residues in both 1918HA1 and 2009HA1. Two mutations-V169I, and T242K-are believed to contribute, though slightly, to the antibody binding in 2009HA1 only after the mutations. They may be newly formed hot spots in the epitope of 2009HA1 after the mutations. The remaining one of the six mutations-E131D-is predicted to contribute to the binding free energy both before and after the mutation.