Mutation detail:
| Mutation site | P474A |
| Virus | Measles virus |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | H |
| Gene ID | 1489801 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | K01711.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Hemagglutinin Protein |
| Uniprot protein ID | P08362 |
| Protein length | 617 amino acids |
| Protein description | Hemagglutinin Protein attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis. |
Literature information:
| Pubmed ID | 19013625 |
| Clinical information | No |
| Disease | - |
| Published year | 2009 |
| Journal | Virology |
| Title | Measles virus attachment proteins with impaired ability to bind CD46 interact more efficiently with the homologous fusion protein |
| Author | Elizabeth A Corey,Ronald M Iorio |
| Evidence | Proteins carrying the following substitutions were prepared by site-directed mutagenesis of the MV H gene from the Edmonston strain: F431S, V451E, Y481N, I473A, P474A, R475A, F476A, K477A, 473-477A, and 473-477A/Y481N. |