Mutation detail:
| Mutation site | 103797A>G |
| Virus | Varicella-Zoster virus |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | ORF61 |
| Gene ID | 1487698 |
| Country | - |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | NC_001348.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Ubiquitin E3 Ligase ICP0 |
| Uniprot protein ID | P09309 |
| Protein length | 467 amino acids |
| Protein description | RING-finger E3 ubiquitin ligase that degrades host SP100, one of the major components of ND10 nuclear bodies, thereby disrupting the organization of these bodies. Plays also a role in the inhibition of host NF-kappa-B pathway by blocking the SCF(BTRC)-mediated addition of ubiquitin chains to host I-kappa-B-alpha/NFKBIA, thereby interfering with its degradation. |
Literature information:
| Pubmed ID | 29242077 |
| Clinical information | No |
| Disease | - |
| Published year | 2017 |
| Journal | Virus Passaged in Cell Culture |
| Title | Vaccine-Type Mutations Identified in Varicella Zoster Virus Passaged in Cell Culture |
| Author | Seok Cheon Kim1 , Youn Hee Won1 , Ji Seon Park1 , Jeong Seon Jeon1 , Jin Hyun Ahn |
| Evidence | Table3 |