Mutation detail:
| Mutation site | 26144C>T |
| Virus | MERS-CoV |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | ORF4b |
| Gene ID | 14254597 |
| Country | Saudi Arabia |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | JX869059.2 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | ORF4b protein |
| Uniprot protein ID | K9N643 |
| Protein length | 246 amino acids |
| Protein description | ORF4b protein is one of the non-structural protein of MERS-CoV. ORF4b protein plays a role in the inhibition of host innate immunity by inhibiting the interaction between host IKBKE and MAVS. In turn, this inhibition prevents the production of host interferon beta. Additionally, inhibits host NF-kappa-B by interacting with host KPNA4 and thereby preventing the translocation of the NF-kappa-B complex into the nucleus by this importin. |
Literature information:
| Pubmed ID | 26484549 |
| Clinical information | No |
| Disease | - |
| Published year | 2015 |
| Journal | EMERGING INFECTIOUS DISEASES |
| Title | Molecular Epidemiology of Hospital Outbreak of Middle East Respiratory Syndrome, Riyadh, Saudi Arabia, 2014 |
| Author | Shamsudeen F Fagbo,Leila Skakni,Daniel K W Chu,Musa A Garbati,Mercy Joseph |
| Evidence | This isolate has a signature mutation (C26144T KFMC-9) that is also present in KKUH-90b, KKUH-291, and KKUH-368 isolates, indicating that patient from which this virus was isolated was infected with a virus related to those in the ongoing outbreak at KKUH |