Mutation detail:
| Mutation site | 8235insC |
| Virus | Measles virus |
Mutation level  |
Nucleotide Level |
| Gene/protein/region type | H |
| Gene ID | 1489801 |
| Country | Argentina |
| Mutation type |
- |
| Genotype/subtype/clade | D6 |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | AF266291.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Hemagglutinin Protein |
| Uniprot protein ID | P08362 |
| Protein length | 617 amino acids |
| Protein description | Hemagglutinin Protein attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis. |
Literature information:
| Pubmed ID | 10568769 |
| Clinical information | No |
| Disease | - |
| Published year | 2000 |
| Journal | Journal of Medical Virology |
| Title | Sequence analysis of measles virus hemagglutinin isolated in Argentina during the 1997-1998 outbreak |
| Author | P R Barrero,C D de Wolff,C A Passeggi,A S Mistchenko |
| Evidence | In 3/46 viruses, guanine deletion at position 8205 changed the reading frame and insertion of an extra cytosine at nucleotide 8235 shifted it back to the original frame. |