Mutation detail:
| Mutation site | L139I |
| Virus | Human respiratory syncytial virus |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | N |
| Gene ID | 1494470 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | U39662.1 |
| Drug/antibody/vaccine | A-33903-resisitant, RSV604-resistant |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Nucleoprotein |
| Uniprot protein ID | P03418 |
| Protein length | 391 amino acids |
| Protein description | Nucleoprotein Encapsidates the viral RNA genome by forming a left-handed helical nucleocapsid that protects the RNA from nucleases. RNA replication depends on the availability of soluble nucleoprotein. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. Together with the phosphoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway. May also act as a modulator of the innate immune response by sequestration of host IFIH1/MDA5 and MAVS into IBs. |
Literature information:
| Pubmed ID | 17576833 |
| Clinical information | No |
| Disease | - |
| Published year | 2007 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Title | RSV604, a Novel Inhibitor of Respiratory Syncytial Virus Replication |
| Author | Joanna Chapman,Elizabeth Abbott,Dagmar G. Alber,Robert C. Baxter,Sian K. Bithell |
| Evidence | The N gene of RSV was also sequenced from viruses obtained from the passages immediately prior to plaque picking. The amino acid substitutions identified were as follows: N105D in the A-33903-resistant RSV from passages 5 and 6 and the plaque-purified vir |