Mutation detail:
| Mutation site | A68V |
| Virus | SARS-CoV |
Mutation level  |
Amino acid level |
| Gene/protein/region type | M Protein |
| Gene ID | 1489672 |
| Country | China |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | AY390556.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Membrane Glycoprotein |
| Uniprot protein ID | P59596 |
| Protein length | 221 amino acids |
| Protein description | The M protein is one of the structural proteins of coronaviruses. It consists of three regions, the N-terminal, C-terminal, and the transmembrane region. The N-terminal is the external region of the M protein and it contains six amino acids and a glycosylation site. The C-terminal region is found at the interior side of the membrane, containing 123 amino acids, and it includesprotein kinase C phosphorylation sites and N- myristoylation sites. The transmembrane region comprises 80 amino acids and three domains. The first transmembrane (TMI) domain is composed of 19 amino acids of a hydrophobic nature, the second transmembrane domain (TMII) contains 23 amino acids of a hydrophobic nature, and the third domain (TMIII) contains 23 amino acids of a hydrophilic nature |
Literature information:
| Pubmed ID | 14752165 |
| Clinical information | No |
| Disease | - |
| Published year | 2004 |
| Journal | Science |
| Title | Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China |
| Author | Chinese SARS Molecular Epidemiology Consortium |
| Evidence | Table s2 |