Mutation detail:
| Mutation site | R44G |
| Virus | Measles virus |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | C |
| Gene ID | 1489805 |
| Country | - |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | D5 |
| Sample |
cell line |
| Variants | - |
| Viral reference sequence | AF266291.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | C protein |
| Uniprot protein ID | P35977 |
| Protein length | 186 amino acids |
| Protein description | The P, V and C proteins are coded by P gene. V is the result of RNA editing and C is coded from an alternative reading frame. These proteins hardly play any role in maintaining viral structure but act as virulence factors to suppress innate immune response in host by interfering with Interferon (IFN) signaling pathway. The P protein establishes connection with both N and L proteins to ensure proper replication and transcription. It acts as a cofactor and is a part of ribonucleoprotein (RNP) complex. |
Literature information:
| Pubmed ID | 22072748 |
| Clinical information | No |
| Disease | - |
| Published year | 2012 |
| Journal | Journal of Virology |
| Title | Measles virus C protein interferes with Beta interferon transcription in the nucleus |
| Author | Konstantin M J Sparrer,Christian K Pfaller,Karl-Klaus Conzelmann |
| Evidence | FIG 3 |