Mutation detail:
| Mutation site | R521K |
| Virus | Measles virus |
Mutation level  |
Amino acid Level |
| Gene/protein/region type | N |
| Gene ID | 1489804 |
| Country | Canada |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | D6 |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | AF266288.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | Nucleocapsid Protein |
| Uniprot protein ID | Q89933 |
| Protein length | 525 amino acids |
| Protein description | Nucleocapsid Protein encapsidates the genome in a ratio of 1 N per 6 ribonucleotides, protecting it from nucleases. The nucleocapsid (NC) has a helical structure with either 12.35 or 11.64 N per turn, approximately 20 nm in diameter, with a hollow central cavity approximately 5 nm in diameter. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. During replication, encapsidation by N is coupled to RNA synthesis and all replicative products are resistant to nucleases. N is released in the blood following lysis of measles infected cells, it interacts then with human FCGR2B on immune cells, inducing apoptosis and blocking inflammatory immune response. Ntail binds to a protein on human thymic epithelial cells, termed Nucleoprotein Receptor (NR), inducing growth arrest. |
Literature information:
| Pubmed ID | 30291564 |
| Clinical information | No |
| Disease | SSPE(Subacute sclerosing panencephalitis) |
| Published year | 2018 |
| Journal | Journal of NeuroVirology |
| Title | Genetic characterization of measles virus genotype D6 subacute sclerosing panencephalitis case, Alberta, Canada |
| Author | K Pabbaraju,K Fonseca,S Wong,M W Koch,J T Joseph |
| Evidence | Mutations found in the Alberta strain not noted in the wild type and SSPE D6 strains included S139N, R213K, R439G, D474N, S479W, and R521K. |