Mutation detail:
| Mutation site | F76L |
| Virus | SARS-CoV |
Mutation level  |
Amino acid level |
| Gene/protein/region type | ORF8b |
| Gene ID | 1489677 |
| Country | China |
| Mutation type |
nonsynonymous mutation |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | AY390556.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
- |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | ORF8b protein |
| Uniprot protein ID | - |
| Protein length | 84 amino acids |
| Protein description | The orf8a and orf8b of SARS-CoV are not essential for viral replication while they are localized in vesiclelike structures in the endoplasmic reticulum, cytosol and nucleus of host cells. The orf8a and orf8b of SARS-CoV stimulate cellular DNA synthesis and caspase-dependent apoptosis. |
Literature information:
| Pubmed ID | 14752165 |
| Clinical information | No |
| Disease | - |
| Published year | 2004 |
| Journal | Science |
| Title | Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China |
| Author | Chinese SARS Molecular Epidemiology Consortium |
| Evidence | Table s2 |