Mutation detail:
| Mutation site | del27122-27535 |
| Virus | MERS-CoV |
Mutation level  |
Nucleotide level |
| Gene/protein/region type | ORF5 |
| Gene ID | 14254598 |
| Country | China |
| Mutation type |
- |
| Genotype/subtype/clade | - |
| Sample |
Human |
| Variants | - |
| Viral reference sequence | KT036372.1 |
| Drug/antibody/vaccine | - |
| Transmissibility |
- |
| Transmission mechanism | - |
| Pathogenicity |
decrease |
| Pathogenicity mechanism | - |
| Immune escape mutation | - |
| Immune escape mechanism | - |
| RT-PCR primers probes | - |
Protein detail:
| Protein name | ORF5 protein |
| Uniprot protein ID | K9N7D2 |
| Protein length | 224 amino acids |
| Protein description | ORF5 protein is one of the non-structural protein of MERS-CoV. ORF5 protein seems to play a role in the inhibition of host innate immune repsonse. |
Literature information:
| Pubmed ID | 28421366 |
| Clinical information | No |
| Disease | - |
| Published year | 2017 |
| Journal | Archives of virology |
| Title | Two deletion variants of Middle East respiratory syndrome coronavirus found in a patient with characteristic symptoms |
| Author | Qian Xie,vujuan Cao,Juan Su,Jie wu,Xxianbo wu |
| Evidence | Deletions of 414 and 419 nt occurred between ORF5 and the E protein, resulting in a partial protein fusion or truncation of ORF5 and the E protein. |